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Patients received vedolizumab at week 0, 2 and 6 and were evaluated for clinical efficacy at week 10.Clinical characteristics and routine laboratory parameters were obtained and patients were classified as responders or non-responders.
To understand more of this complex acclimation process, we studied the expression patterns of the signal transducing pathways, including signal perception, the circadian clock and phospholipid signalling pathways, upstream of the CBF gene regulatory hub.
The values on the X-axes show the time in hours after dawn.
The white and black bars symbolise the light and dark periods, while grey bars indicate subjective night.
We aimed to investigate chemokine levels in serum of IBD-patients treated with vedolizumab.
In this pilot study, we included 11 IBD patients (8 Crohn’s disease, 3 ulcerative colitis) previously non-respondent to anti-tumor necrosis factor (TNF)-agents.